Why Calorie Restriction Might Prolong Life - Health and living: nutrition, diet, fitness, recipes, prevention information - MedicineNet.com
옛말 그른 거 없다... 조금 먹어야 오래 사는 것 같단다... =.=
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Why Calorie Restriction Might Prolong Life
By Amanda Gardner
HealthDay Reporter
WEDNESDAY, May 2 (HealthDay News) -- Scientists have long known that eating less translates into longer life, at least in worms and mice.
Now, researchers report that they think they know why this phenomenon of "dietary restriction" increases longevity: It all revolves around a gene known as pha-4, which is involved in the embryonic development of the intestine in the C. elegans roundworm.
"After 72 years of not knowing how calorie restriction works, we finally have genetic evidence to unravel the underlying molecular program required for increased longevity in response to calorie restriction," said study senior author Andrew Dillin, an associate professor in the Molecular and Cell Biology Laboratory at the Salk Institute in La Jolla, Calif.
"This suggests that there could be specific genetic pathways that modulate organisms' response to caloric restriction. If there are, we can now screen to find drugs to modulate," said Heidi A. Tissenbaum, an associate professor in the Program in Gene Function and Expression at the University of Massachusetts Medical School. "Also, very few people have looked at genes in embryogenesis and how they affect adult life span. Not only does this have an effect on what we understand about dietary restriction, but also what we understand about longevity. Genes that play critical roles in embryogenesis might be critically important in the aging process," she added.
Dillin reported the findings, which were expected to be published in the May 2 online issue of Nature, at a news conference Tuesday...
Why Calorie Restriction Might Prolong Life
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
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Why Calorie Restriction Might Prolong Life
By Amanda Gardner
HealthDay Reporter
WEDNESDAY, May 2 (HealthDay News) -- Scientists have long known that eating less translates into longer life, at least in worms and mice.
Now, researchers report that they think they know why this phenomenon of "dietary restriction" increases longevity: It all revolves around a gene known as pha-4, which is involved in the embryonic development of the intestine in the C. elegans roundworm.
"After 72 years of not knowing how calorie restriction works, we finally have genetic evidence to unravel the underlying molecular program required for increased longevity in response to calorie restriction," said study senior author Andrew Dillin, an associate professor in the Molecular and Cell Biology Laboratory at the Salk Institute in La Jolla, Calif.
"This suggests that there could be specific genetic pathways that modulate organisms' response to caloric restriction. If there are, we can now screen to find drugs to modulate," said Heidi A. Tissenbaum, an associate professor in the Program in Gene Function and Expression at the University of Massachusetts Medical School. "Also, very few people have looked at genes in embryogenesis and how they affect adult life span. Not only does this have an effect on what we understand about dietary restriction, but also what we understand about longevity. Genes that play critical roles in embryogenesis might be critically important in the aging process," she added.
Dillin reported the findings, which were expected to be published in the May 2 online issue of Nature, at a news conference Tuesday...
Why Calorie Restriction Might Prolong Life
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
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